Route 1. Take the Hume Hwy to Wangaratta then the Great Alpine Road direct to Hotham, or the Snow Road via Milawa & Oxley to Myrtleford, Bright, Harrietville & Hotham. Travel time around 4.25 hours with a distance of 380km..
Route 2. Take the Monash Freeway (which turns into the Princes Hwy) to Bairnsdale, then Omeo, then the Great Alpine Road to Hotham past the Hotham Airport and Dinner Plain. Travel time around 5.5 hours with a distance of 460km.
Take the Hume Hwy to Albury-Wodonga and follow the snow signs to Yackandandah then turn off to Myrtleford. At Myrtleford turn onto the Great Alpine Road to Bright then Harrietville and Hotham. Travel time around 8 hours.
Take the Mallee Highway to Ouyen, connect to the Murray Valley Highway to Swan Hill, the Midland Highway to Shepparton, then take the Hume Highway to Wangaratta, followed by the Great Alpine Road direct to Hotham. Travel time around 12 hours.
Drive south along the Newell Highway across NSW via Tocumwal and Cobram then across to Wangaratta. Take the Great Alpine Road direct to Hotham via Bright and Harrietville. Travel time around 15 hours.